Browse Categories

Nitrile Allergies?

< by Fritz Maskrey, Vice President, Business Development, TechNiGlove International
TechNiGlove’s Fritz Maskrey looks at the allergic reaction that’s come to be known as a “nitrile allergy.”

When one thinks of allergies in the disposable glove world, the words "natural rubber" immediately come to mind. The simple solution for such a problem was introduced in the 1990s using synthetic polymers. This new material would mimic the properties of natural rubber, without the protein allergens that were causing some users to develop allergic reactions. Hence, the product we know today as "thin-walled, disposable nitrile gloves" was born.

NITRILE GLOVE PRODUCTIONLiquid nitrile is refined and coated onto a ceramic former, then cured into an elastic polymer in the desired shape. The elastic polymer, which has been molded into the shape of varying sizes and lengths of a glove, is then double-chlorinated inside and out and finally processed to meet the specifications of whichever cleanroom environment the product is intended to meet.

Since the inception of nitrile, manufacturers have been in competition to create a better and more efficient process with which to make gloves. The outcome of such competition has been the addition of certain accelerators whose job it was to decrease the time needed for a glove to cure, reduce the cost of the overall material in use, give the material a softer feel, or any other attempt at giving the customer an overall lower cost and higher-performing item.

Certain sulfur-based chemicals have been developed to accomplish the previously mentioned goal. These chemicals have incredibly complicated chemical structures and even more complicated scientific names to go along with them. While this list of chemicals can have a litany of positive effects, the unfortunate side effects of such chemicals can be an allergic reaction (now known as "nitrile allergies") similar to that of latex.

Here are current examples of accelerators used in glove production:
  • N-cyclohexyl-2-benzothiazole sulfenamide
  • 2-Dibenzothiazole Disulfide
  • Tetramethylthiuram Disulfide
  • Diphenylguanidine
  • 2-Mercaptobenzothiazole
  • 3-Methylpiperidine

Well, yes...and no. The good news is that most of these allergies are not to nitrile itself, they are simply allergic reactions to the chemicals that are used in the manufacturing process of such gloves. The specific allergic reaction is known as “Type 4” which is defined as:
Netrile Gloves
"Allergies ‘Type 4’ are also called cell-mediated or delayed allergies. When T-cells become activated and result in an inflammation of the affected area. Unlike other type of allergies, Type 4 is not antibody related, but rather is a type of cell-mediated response."
One of the newer technologies being utilized in the production of thin-walled disposable gloves is "accelerator-free" nitrile. Production managers, line engineers, and corporate purchasers need be aware of this and not dismiss it as a marketing term, as it can drastically affect any users with a Type 4 allergy.

Visit Q Source’s TechNiGlove Department for information about, and to purchase, a wide selection of nitrile gloves including their Rival (RV400 Series) accelerator-free, low ex-tractable, powder-free nitrile examination gloves. Please contact us directly (via email or phone at 855-944-0693) for inquiries about TechNiGlove’s Rival CR (RVCR1500 Series) soft modulus, accelerator-free, powder-free nitrile gloves for controlled environments.

Thanks, Fritz! Awareness of potential nitrile allergies is very important. We appreciate you sharing your expertise with the Q Source community.

TechNiGlove International is a leading manufacturer of disposable gloves for contamination-controlled environments. TechNiGlove's Nitrile, Sterile Nitrile, and Latex Gloves offer consistent quality for use in cleanrooms, sterile non-medical environments, pharmaceutical, and industrial settings.

Subscribe to our email newsletter for additional Q Source product information, reviews, how-to articles, and special offers.


Q Source Guest Blog ESD My Account Web account Transforming Technologies bevco guest blog signs wish lists search history Bevco ANSI/ESD importance of ergonomics us made healthy ergonomics easy assembly q source 40 celebrates blog tools composite decking decking bench magnifier vision engineering vision luxo file attachments upload attach files purchase order tax exempt form account holder social distancing employee safety customer safety metcal introducing gt90 and gt120 unitron track orders re-order holiday July 4th office closure Independence Day wastebaskets PCBs ANSI/ESD S2020 workstations conductive static dissipative Brady arc flash pipe markers labels lockout tagout self adhesive identification ASG Jergens torque threaded fasteners ISO 5393 NIST 35th anniversary 1984 customer service Q Electronics Steve Quail Gus Lugten industrial assembly production miscellaneous Web site features order templates express checkout quick order company logos Simonds ergonomic tools cutters crimpers pneumatic Shopping Tools favorites frequent orders checkout defaults carts Atrix Omega cordless vacuum immediate containment promo ULPA SMTA Long Island workshop Deadly Sins of SMT Phil Zarrow assembly process stereo microscope On the Bench how-to focus Unitron Peter Indrigo video Z10 Series eyestrain ergonomic seating musculoskeletal disorders Department of Labor National Research Council National Safety Council soldering comic books smt surface mount technology Mighty Ohm Silicon Farmers Mitch Altman Andie Nordgren Jeff Keyzer Greg Peek Dave Roberts Nitrile allergies latex rubber gloves TechNiGlove Fritz Maskrey Type 4 disposable gloves 4500 Series rubber table mats free shipping static control order tracking recent web orders user info shopping tools account tools backless stools ErgoLux ErgoLux Jr Versa Maintenance Repair ANSI-BIFMA Greenguard Gold lab medical cleanroom industrial electronic assembly quotes orders shopping Quantum Storage Systems Free Shipping Bins Totes Carts Shelving Static Solutions hand lotion EOS/ESD personal grounding wrist straps heel grounders Craig Zander Walking Voltage Test flooring footwear Warmbier WT5000 EFM51WT web account nitrile gloves
Show All


2024 2023 2022 2021 2020
November October August July June April March January
December October September July June May April March February